LAB MEMBERS

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DR ANTON CALABRESE

Sir Henry Dale Fellow and University Academic Fellow
Group Leader

Anton completed a PhD in 2013 at the University of Adelaide under the supervision of Prof John Bowie and Dr Tara Pukala. His PhD work focused on the development of novel negative ion-mass spectrometry amenable crosslinking reagents and the study of amphibian antimicrobial peptides. In 2013 Anton relocated to the University of Leeds as a postdoctoral researcher working with Prof Alison Ashcroft, Prof Sheena Radford FRS and Prof Peter Henderson. During his postdoctoral studies, Anton developed new methods in native mass spectrometry, chemical crosslinking and fast photochemical oxidation of proteins and used these methods to study systems spanning membrane proteins, chaperones and amyloid. In January 2020 he began a new role at the University of Leeds as a University Academic Fellow and Group Leader in Biological Mass Spectrometry. Outside of the lab Anton likes to travel, spend time at his allotment, cook, and enjoy good beer and wine!

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DR TOM MINSHULL

Research Fellow

I Completed my PhD in 2016 at the University of Sheffield. My PhD was a multi-disciplinary project between the Departments of Infection and Immunity and Chemical and Biological under the supervision of Prof Rob Read and Prof Mark Dickman. My project focused on the epigenetics of sepsis. Specifically, I used Mass Spectrometry to characterise global and combinatorial patterns of Post translation Modifications present on histone proteins in both in-vitro and in-vivo systems. Following this I moved into industry, developing mass spectrometry and other analytical techniques to characterise a wide range of biological systems, including secretome analysis, bio-conjugation characterisation and disulphide mapping of pre-clinical and clinical stage Biopharmaceuticals. I Joined the Calabrese lab in May 2021, as a Research Fellow. My research focuses using new and exciting methods in mass spectrometry to study the mechanisms and dynamics of higher order assemblies involved in ALS. Outside of the lab, I have a love of Cooking and Cricket (when it’s not raining).

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ALICE COLYER

Postgraduate Researcher

I joined the lab in October 2020. My PhD project is to explore the mechanism of viral factory formation, to hopefully aid the development of novel antivirals. I completed my MSc in Infection, Immunity and Human Disease in September 2020 at the University of Leeds. My research project with Dr. Brian Jackson focused on protein-protein interactions between host cell and KSHV infected cells through STIP1 protein folding and chaperone pathways in the hope to find novel antiviral targets for KSHV. Outside the lab, I enjoy exploring new places in Leeds and beyond as even after 4 years here there's still so much to see!